Murray has been vaccinated and also has first-hand experience of the severity of the virus, having contracted Covid himself at the start of the year.
He expects the split between vaxxers and anti-vaxxers to intensify at January’s upcoming Australian Open, where the two camps are likely to be treated in different ways.
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"I can see it's going to become an issue over the coming months," said Murray, who is due to play third seed Stefanos Tsitsipas at Monday’s US Open.
"The conversations with regards to the Australian Open are already happening. The players that have been vaccinated are going to be having very different conditions to players who are not vaccinated."
There will have to be "a lot of pretty long, hard conversations" between tours and players over the issue, he added
Ease Covid curbs in Wales or people could lose teeth, dentists say
People face losing teeth if Covid rules in Wales are not eased to let more patients get check-ups, leading dentists have warned.
The British Dental Association said it wants curbs for dentists eased now most of Wales' Covid restrictions have lifted.
Russell Gidney, chair of the BDA's Welsh general dental practice committee, said delays could mean tooth decay, gum disease and cancer risk going unnoticed.
Routine appointments were postponed when Wales entered lockdown in March 2020 and dentists only saw patients face-to-face for urgent care, and strict hygiene and ventilation measures now make treatments much longer for practices.
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By the time it causes problems, we are often talking towards root fillings or teeth coming out, and then you've got things like gum disease or cancer, where there can be no symptoms," told the BBC.
Booster vaccine rollout ahead of winter delayed
The planned rollout of Covid-19 booster vaccines is to be delayed, as ministers and scientists await the outcome of a major clinical trial.
The NHS had been preparing to begin administering third doses of vaccines from September 6, but The Telegraph understands that the programme would now only begin in the middle of the month as the decision has come “down to the wireâ€.
The Joint Committee on Vaccination and Immunisation (JCVI), which advises ministers on the rollout of vaccines, has been awaiting the results of the Cov-Boost study, led by the University Hospital Southampton NHS Foundation Trust, which is examining the impact of a third dose on patients’ immune responses.
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Once the panel has the data, it will draw up final advice on whether boosters should be rolled out to all over-50s, or just to the most vulnerable patients.